Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae.

Patterns of Correlation between Genes and Metabolites Depend on the Experimental Condition and the Type of Metabolite While the above approach is adequate to reveal an overall trend for co-regulation of functionally related genes and metabolites, the nature of the co-regulation could vary depending on the experimental condition and the functional role of the metabolite involved.

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We examine whether transcripts and metabolites are co-regulated in general, and demonstrate the existence of a strong trend for correlated genes and metabolites to participate in related biological processes.

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