Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage.

Acetyl-H3 (Ac-H3), an indicator of active gene transcription was employed as a positive control and demonstrated a highly significant 200-fold enrichment at the dUTPase promoter ( Figure 2 D).

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However, Sp1 overexpression resulted in only a modest increase in luciferase activity of the pGL3:Sp1Δ which did not reach statistical significance (data not shown).

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