Barely Significant
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Pharmacotherapeutics of epilepsy: use of lamotrigine and expectations for lamotrigine extended release.

Ther Clin Risk Manag · 2008 · PMC2621406 · PMID 19209284

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The difference between once and twice daily did not reach statistical significance though the difference between once and three times and once and four times per day did.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.