Animals implanted with 5,000 CD133 expressing LA-N-5 cells demonstrated earlier tumor formation and larger size compared to CD133 null cells (p = 0.03), though the frequency of tumors did not reach statistical significance in this small experiment (p = 0.13 by Fisher's Exact test) ( Fig. 6B, C ).
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Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus.
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