Barely Significant
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Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD.

Int J Chron Obstruct Pulmon Dis · 2008 · PMC2629970 · PMID 18686739

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The difference between the tiotropium and the placebo group was, despite the consistent effect of tiotropium, small and did not reach statistical significance in less severe patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.