Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.

We again confirmed a highly significant association in an overall analysis stratified for the populations, with an odds ratio of 0.46, 95% CI 0.35–0.60, P = 8.94 × 10 −9 (Table 1 ).

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The combination of some of the Dutch study samples with further samples from an Irish population detected DPP6 as the most strongly associated variant but this did not reach statistical significance ( 8 ).

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