Correlation of enhanced thrombospondin-1 expression, TGF-beta signalling and proteinuria in human type-2 diabetic nephropathy.

Differentiation of diabetic nephropathy in three stages of severity demonstrates that in milder diabetic lesions, glomerular and tubulointerstitial, an increase of TSP-1 can be seen (stage 1: 1.98 ± 1.98, stage 2: 1.47 ± 1.94% positive area, Figure 1 E–G), but did not reach statistical significance compared to controls due to the low number of biopsies for these groups (stage 1: n = 5, stage 2: n = 5) and a significant variation of diabetic disease and TSP-1 expression in individual glomeruli within the same biopsy.

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