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Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality.

Rheumatology (Oxford) · 2009 · PMC2639482 · PMID 19056799

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We have also observed an increased risk of cardiovascular mortality that we had not observed in our previous study, although that relationship did not reach statistical significance after adjustment was made for putative confounding factors.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.