Genome-wide and candidate gene association study of cigarette smoking behaviors.

The direction and significance of correlations among the smoking phenotypes within the dataset are similar, with all correlations highly significant (P<0.0001), except for the correlation between age at initiation and cigarettes per day in the NHS sample ( Table S2 ).

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The cytochrome P450, cell cycle control, and alcohol dehydrogenase candidate genes groups also exhibited nominally significant (0.01<P permuted <0.05) associations with smoking behaviors ( Table 4 ).

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