Interestingly, the cAMP- and 8-Cl-cAMP–induced stimulation of PKA activity in proteins from visceral adipose tissue of obese patients was significantly lower than that observed in samples from nonobese patients, whereas the difference did not reach statistical significance in subcutaneous adipose tissues ( Fig. 4 ).
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Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects.
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