Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation.

Furthermore, although small decreases in mean cell viability were observed with both rAD-TK–and rAD-β-gal—treated islets compared with untreated islets, these reductions did not reach statistical significance (supplementary Fig. 1 B ), indicating that 250 MOI was an appropriate dose for further studies.

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