Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain.

J Exp Med · 2009 · PMC2646573 · PMID 19171765

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0.5500

closest p · 11.0× alpha

0.5500

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did not reach statistical significanceP = 0.55not close (p > 0.1)

Removal of other N -glycosylation sites also appeared to increase functional avidity, but these changes did not reach statistical significance (vα13-D3 v-24 /vβ6 WT , Δlog EC50 = 0.3 and P = 0.55; vα13-D3 WT /vβ6 c-116 , Δlog EC50 = 0.8 and P = 0.07; and vα13-D3 c-90 /vβ6 c-116 , Δlog EC50 = 0.3 and P = 0.15).

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