Identification of coevolving residues and coevolution potentials emphasizing structure, bond formation and catalytic coordination in protein evolution.

PLoS One · 2009 · PMC2651771 · PMID 19274093

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a significant trendno p-value reported

We also demonstrate a significant trend for those residues that are annotated as participating directly in a protein's catalytic activity to coevolve with each other.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.