Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma.

Although the difference in life-expectancies between carriers and non-carriers for females and males separately was only marginally significant at the 0.05 α -level, a test of association for the difference combining males and females based on Fisher's sum of chi-square statistics was significant with a p-value of 0.024.

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