Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.

Co-transfection of Kv1.3 + TrkBShc- plus nShc cDNA exhibited BDNF-induced current suppression of Kv1.3 (533 +/- 109 pA (time 0) versus 473 +/- 115 pA (time 20) that did not reach statistical significance (not significantly different paired t -test, α ≤ 0.05; n = 10, 89% suppression) compared with that observed with Kv1.3 + TrkB co-expression (356 +/- 71 pA (time 0) versus 298 +/- 64 pA (time 20); significantly different paired t -test, α ≤ 0.05; n= 5, 84% suppression) (Table 2 , Fig. 10B, C ).

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