Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.

ZOL-treated monocytes induced a 2·5 ± 1·2-fold ( n = 3) increase in IFN-γ release when co-cultured with monocyte-depleted PBMCs, as compared to co-culture of monocyte-depleted PBMCs with vehicle-treated monocytes ( Fig 2A ), although this did not reach statistical significance.

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