Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.

Across the BP related traits, the most significant associations were seen with the low frequency haplotype pool, which drive the highly significant global associations.

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Although the associations did not reach statistical significance in some of the individual cohorts, for the majority of populations, the direction of the effect was consistent with that seen in BRIGHT, with overlapping 95% confidence intervals.

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