Peripheral artery disease: potential role of ACE-inhibitor therapy.

In the analysis of the 637 patients who completed carotid ultrasonography examinations, ramipril had a highly significant effect on the single maximum IMT slope (p = 0.003 for the overall effect of ramipril versus placebo and p = 0.008 for ramipril 10 mg/day versus placebo).

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There was an overall effect of ramipril, which reduced the annualized slope of the mean maximum IMT (intimal medial thickness) versus ramipril placebo (p = 0.033), and there was a strong trend for benefit in the ramipril 10 mg/day group versus ramipril placebo (p = 0.028).

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