Orientation, distance, regulation and function of neighbouring genes.

We found a highly significant excess of genes involved in DNA metabolism and repair (Table 1 ), confirming previous observations [ 13 ] and supporting a biological importance of this gene arrangement.

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We found a significant trend for an increase in D with increasing intergenic interval size above 500 bp and up to 50 kb, and no change thereafter for all intervals (Figure 9 ).

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