Anti-idiotypic antibodies: a new approach in prion research.

All three concentrations of the purified Ch5 chicken polyclonal Ab (10, 1 and 0.1 μg/ml) caused large and highly significant (p < 0.004) signal decreases, of 88%, 84% and 81%, relative to the positive control.

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A 50 μg/ml concentration of 5D12 still caused a significant, 52% drop in signal, whereas further dilution of 5D12 to 10 μg/ml had a lesser effect, reducing the signal by 39%, which did not reach statistical significance.

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