Complete proteome scans In order to gain some evolutionary insight concerning disordered binding sites, the predictor was run on the 736 complete proteomes (53 archaea, 639 bacteria and 44 eukaryota, see Dataset S5 , Dataset S6 , and Dataset S7 , respectively) that are currently available from the SwissProt database ( ftp://ftp.expasy.org/ ). In agreement of previous analyses [5] , [6] there is a clear trend of increasing amount of protein disorder as the complexity of the organism increases (see Figure 8 ).
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