Although, due to the small number of samples tested, the difference did not reach statistical significance, a higher level of AID expression in patient CD27 − B-cells was observed (40.3±33.1 vs 12.6±2.7 in controls), whereas a lower level of AID expression was observed in the CD27 + compartment for patients (9.7±8.0 vs 64.0±37.0 in controls).
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CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection.
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