The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding.

The polymerase activities were increased with the PA-H/W chimeras, compared to wild-type WSN, in both the ApG-primed transcription assay ( Figure 4C , lane 4) and the globin mRNA-primed transcription assay ( Figure 4D , lane 4), whereas the slight increase in activity with the PA-W/H chimera ( Figure 4D , lane 3) was only marginally significant.

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