Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction.

The inhibitory effect of the Rho kinase inhibitor Y27632 and the L-type calcium channel blocker nifedipine on ceramide-induced contraction did not reach statistical significance, but the effects of both drugs combined were highly significant ( Figure 4 D ). 3.5 Hypoxic K V channel inhibition As expected, 1 , 2 we found that hypoxia inhibited K V currents ( Figure 5 ) with a similar time course to the hypoxia-induced ceramide production and contraction.

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