Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women.

After confirming that the haptoglobin genotype was distributed according to Hardy-Weinberg equilibrium in both PCOS patients and controls (data not shown), we found that the Hp 2 allele was more frequent in the former (62% vs 52%, χ 2 = 5.191, P = 0.023), explaining a borderline significant tendency towards a higher frequency of Hp 2 /Hp 2 genotype, and to a reduced frequency of the Hp 1 /Hp 1 genotype, in PCOS patients compared with the controls ( Table 3 ).

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Of note, chronic inflammation might play a similar role, yet the tendency towards an increase in serum C-reactive protein levels in women presenting with abnormal glucose tolerance did not reach statistical significance.

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