How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design--a reanalysis of 4 trials.

Trials · 2009 · PMC2680399 · PMID 19374739

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only marginally significantno p-value reported

While the results for comparisons A vs B, A vs D and A vs E are in line with the analysis given in table 1 , comparison A vs C is only marginally significant if a late stage 1 analysis is conducted (HR of 0.86 if the first stage analysis is conducted at a significance level of 0.1).

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