Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer.

Exemestane induced a non significant increase in the mean annual rate of BMD loss at lumbar spine with respect to placebo (2.17% vs 1.84%) and a slightly significant increase in femoral neck BMD (2.72% vs 1.48%; p = 0.02) ( Lonning et al 2005 ).

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