22 Another study of duloxetine versus placebo in women with SUI showed a trend towards an increase in Valsalva leak point pressure and urethral pressure profile parameters in women taking duloxetine. 23 A study of the effect of duloxetine on urethral pressure and sphincter morphology showed significant increases in mean urethral retro-resistance pressure, maximum urethral closure pressure and sphincter width after 8 weeks’ treatment with duloxetine. 24 A sub-analysis of women who had a symptomatic improvement with duloxetine revealed these increases to be even more marked.
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