Renin-angiotensin-aldosterone system in the elderly: rational use of aliskiren in managing hypertension.

The study was stopped prematurely by the data safety monitoring board because of a highly significant (p = 0.003) 43% reduction in stroke by the calcium channel blocker.

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At the 36-week end point, aliskiren-based treatment was non-inferior to ramipril based treatment although the difference (−1.92, 95% CI −4.03 to 0.19, p = 0.0747) did not reach statistical significance.

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