Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis.

Cancer Cell Int · 2009 · PMC2687411 · PMID 19422694

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The finding that SFRP1 down-regulation promotes anoikis resistance, migration as well as invasion, and increases the population of CD44 High /CD24 low is quite significant because it may partially explain why breast tumors with lost SFRP1 expression are associated with poor patient prognosis.

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