The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus.

Genome Biol · 2009 · PMC2688270 · PMID 19216739

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a clear trendno p-value reported

Nevertheless, these plots show a clear trend towards higher energies from year to year, which would favor adaptation to human hosts according to our hypothesis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.