Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis.

AdAg85A vaccine i.n and i.m boosting to BCG-immunized animals further significantly enhanced it to 467 and 412 days, respectively although the differences between BCG and BCG/Ad i.m groups did not reach statistical significance ( Fig. 5 ; p = 0.02 BCG/Ad i.n compared to BCG alone; p = 0.12 BCG/Ad i.m compared to BCG alone).

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