Rational use of the fixed combination of dorzolamide - timolol in the management of raised intraocular pressure and glaucoma.

However, in the replacement study designed to mimic the “real world” uncontrolled clinical practice setting, there was a highly significant (p < 0.0001) IOP effect when switching from the concomitant use of the individual components to the FCDT, as 81.1% patients had an IOP equal to or less than the starting IOP.

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The FCDT showed a significantly greater incidence of taste perversion (p < 0.001) and stinging upon instillation (p = 0.036), while latanoprost showed a trend for increased conjunctival injection (p = 0.056).

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