Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia.

The other major schizophrenia candidate risk factor genes, COMT (r = -0.33; q = 0.16), DTNBP1 (r = 0.35; q = 0.14), DISC1 (r = -0.40; q = 0.08) and RGS4 (r = 0.39; q = 0.09), all showed trends but did not reach statistical significance for correlation with the template.

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The other two genes were also positively correlated but did not quite reach significance ( CLDN11 r = 0.42, q = 0.06; MOBP r = 0.35, q = 0.14).

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This finding was replicated in our results (Figure 4b , with the glucocorticoid receptor gene NR3C1 showing a highly significant positive correlation with the template (q = 0.008) and all 5 probe-sets for this gene showed q values ≤ 0.07.

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