Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

PLoS Genet · 2009 · PMC2694358 · PMID 19557189

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

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boldest claim

The sentences

nominally significantp <5×10 −5actually significant

A recent GWA meta-analysis in Crohn's disease identified 74 independent SNPs as nominally significant ( p <5×10 −5 ) [24] .

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highly significantno p-value reported

Two emerge with highly significant GRAIL scores: rs8178556 on chromosome 21 ( IFNAR1 , p text = 1.7×10 −4 ) and rs12928822 on chromosome 16 ( SOCS1 , p text = 8.2×10 −4 ) suggesting these independent regions may lead to novel associated SNPs for Crohn's disease (see Table S7 ).

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