Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.

In the case of 4E-BP2, there was a nonsignificant trend for high scores to associate with good prognosis.

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This variable has a highly significant relationship with survival but this should be treated with caution because the constants were determined using regressions for OS, and, thus to an extent, significance is self fulfilling, at least for OS.

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This was shown by the observations that expression of 4E-BP2, but not 4E-BP1, showed a trend towards being a prognostic factor alone ( Figure 2E , Supplementary Figure S5B ), provided an improved prognostic indicator in combination with eIF4E ( y ), and was the most statistically significant component of z after eIF4E itself.

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