Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer.

HnRNP K undergoes progressive increase from NHP to NT to PCa; the differences in expression were significant between NT and PCa ( P =0.0003), between NT and PCa with low-intermediate Gleason scores ( P =0.014) and highly significant between low-intermediate and high Gleason scores ( P =0.008).

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No significant correlation was found between both nuclear and cytoplasmic hnRNP K immunostaining and clinicopathological variables; however, the patients ( n =24) with low total scores (<10) showed a trend towards better outcomes, which, however, was not statistically significant ( P =0.085) ( Figure 1D ).

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