Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level.

There was a strong trend for inhibition of neuronal hyperexcitability from 10 – 30 min compared to DMSO administration and just like rapamycin, AUC analysis confirmed that overall, anisomycin elicited a significant reduction in the second phase of the formalin test (Figure 2B ).

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