Linkage of osteoporosis to chromosome 20p12 and association to BMP2.

Since this adjusted p value still has not taken into account the relatedness of the patients, the multiple phenotypes tested, and the other LD blocks in the region, we consider hapC at best marginally significant with the Icelandic data alone.

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The Ser37Ala missense variant is nominally significant for osteoporotic fractures, with an estimated RR of 4.2, and hapB is nominally significant for low BMD, with an estimated RR of 2.1.

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We found highly significant linkage to Chromosome 20p using this approach, discovered variants in the bone morphogenetic protein 2 gene ( BMP2 ) that are associated with osteoporosis, and confirmed the BMP2 association in a cohort of Danish osteoporosis patients.

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