Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer.

Both low GM3 expression and high pSTAT3 expression were associated with a worse survival, which reached near significance for GM3 ( P = 0.08).

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Using the median value as cut off, NSCLC patients with low GM3 expression (median percentage of GM3-positive cells, 91%) or high pSTAT3 expression (median number of pSTAT3 positive cells multiplied by intensity of staining [see Materials and Methods], 110) tended to have a worse overall survival, although this did not reach statistical significance (Figure 1C ).

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