Changing the burden of COPD mortality.

A notable trend in the US COPD mortality data is increased mortality in women in general (with the total number of women dying from COPD now exceeding that for men) and for white women in particular.

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However, a pooled analysis of data from randomized, placebo-controlled trials from the 1990s comparing ICS with placebo (with primary endpoints other than mortality) indicated a strong trend in favor of ICS improving mortality versus placebo (RR for mortality = 0.78; 95% CI: 0.58, 1.05), although statistical significance was not reached ( Table 3 ) ( Sin et al 2003 ).

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