highly significantP < 0.001
In hypoxia, 19 ± 9% of motile mitochondria showed anterograde movement in shRNA-transfected cells, whereas 79 ± 6% showed retrograde movement, a highly significant difference (P < 0.001, t test; n = 5; Fig. 10 C ).
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HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.
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0.0010
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Anterograde transport velocity was diminished in hypoxia compared with normoxia, but this difference did not reach statistical significance (P = 0.23 and P = 0.08 for scrRNA and shRNA comparing normoxia and hypoxia, respectively; n = 5).
Although a small trend toward reduced anterograde transport was observed in normoxia, this small change was not significant ( Fig. 10 C ).