Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

J Exp Med · 2009 · PMC2715056 · PMID 19468064

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not fully significantno p-value reported

Although not fully significant, this result indicates an unusual frequency of replacement polymorphic variants and, together with the deeper-than-average TMRCA, is in line with balancing selection rather than with functional relaxation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.