For the gene list downregulated in T1D subjects, there was a near-significant enrichment (EASE score<0.06) of terms related to cell migration/motility , cytokine binding, MHC class II receptor activity, chemokine receptor activity , chemokine receptor & MHC Class II, alpha chain .
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Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.
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