Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a cohort study.

Consequently in patients the reduced capacities to produce both mediators did not reach statistical significance until 12 hours after trauma (TNFα: 47.2 ± 5.9%, IL-6: 38.0 ± 2.8), touching bottom after 24 hours (TNFα: 38.0 ± 6.1%; IL-6: 32.9 ± 2.9%), and slowly rising again to nearly admission values 72 hours after injury (TNFα: 68.5 ± 6.3%; IL-6: 49.7 ± 5.0; Figures 1a and 1c ).

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