Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.

Although, as expected, these correlations are highly significant, the proportion of HIF-binding loci associated with HIF-inducible transcripts was still well below 50%.

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In contrast to prediction, across these common sites, HIF-2α showed a trend to greater maximum enrichment than HIF-1α ( Fig. 4 ).

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