In the endocardium, the maximum gradient was also larger in KCNE1 −/− hearts than in WTs hearts, though this did not reach statistical significance, with gradients of 1.11 ± 0.21 versus 0.69 ± 0.04 in KCNE1 −/− and WT hearts, respectively ( n = 6 in both cases).
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Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome.
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