Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke.

Although there is no significant difference in neurological deficits between MK-801 and control-treated animals, a Kruskal-Wallis test indicates a borderline significant improvement after MK-801 treatment on day 2 (P = 0.056) (Figure 2D ).

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MK-801 showed an improved weight gain from 1 to 2 weeks post-surgery compared to controls, although this did not reach statistical significance (Figure 3B , F (1,8) = 0.566, P = 0.473).

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We previously reported a highly significant correlation of MRI lesion volume with neurological score and the BAT in the cortical infarct model but there was a less significant correlation between neurological score and the BAT [ 13 ].

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