After copy number correction, the total SNCA concentration in the mouse blood showed a trend for the reduction in the PD risk-associated Rep1-261 bp animals, but the variability, in particular within the Rep1-259 bp genotype, was large (Fig. 7 B).
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Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.
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