Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions.

However, for the top 300 bound regions, there is an obvious further preferential overlap among A-P early regulators as well as a moderate preference among the A-P pair rule factors and the D-V factors (Bonferroni corrected Mann Whitney tests suggest that, taken collectively, the preferential co-binding among A-P early regulators is highly significant ( P < 9 × 10 -15 ), while that among the A-P pair rule factors and the D-V factors is moderately significant ( P < 2 × 10 -3 ) for both; Additional data file 13).

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